Malformations in Rat Fetuses Induced by Trypan Blue
نویسندگان
چکیده
منابع مشابه
Trypan blue induced teratogenesis of rat embryos cultivated in vitro.
Trypan blue is known to produce embryonic abnormalities in a wide variety of animals, including rats (Gillman, Gilbert, Gillman & Spence, 1948), mice (Waddington & Carter, 1953; Hamburgh, 1954), amphibians (Waddington & Perry, 1956), chickens (Beaudoin & Wilson, 1958;Stephan & Sutter, 1961), rabbits (Ferm, 1956), and hamsters (Ferm, 1958). Studies on the teratogenic action of this dye have also...
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Repeated injections of trypan blue into the s.c. tissue of inbred Wistar rats induced tumors in the liver. A sequence of morphological changes has been observed during induction of the tumors, and these were studied ultrastructurally. The earliest recognized change was the appearance in the portal tracts of focal collections of monocytic cells that resembled Kupffer cells. They appeared either ...
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as evidence of autoimmune phenomena. The experimental production of positive antiglobulin tests by drugs and chemical agents, however, has suggested that nonimmunologic mechanisms may also be responsible for protein coating of erythrocytes.2’3 During attempts to produce tumors of the reticuloendothelial system in rats by injection of trypan blue, an anemia, chacacterized by increased ervthrocyt...
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cyclophosphamide (cp) is a mustard alkylating agent used in the treatment of a number of neoplastic diseases and as an immunosuppressant for the prevention of xenograft rejection. there are many reports that the teratogenic effects of cyclophosphamide can be prevented by application of antioxidant drugs and stimulation of the maternal immune system. also, there is some evidence that l-carnitine...
متن کاملTrypan blue exclusion assay by flow cytometry
Dye exclusion tests are used to determine the number of live and dead cells. These assays are based on the principle that intact plasma membranes in live cells exclude specific dyes, whereas dead cells do not. Although widely used, the trypan blue (TB) exclusion assay has limitations. The dye can be incorporated by live cells after a short exposure time, and personal reliability, related to the...
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ژورنال
عنوان ژورنال: Experimental Animals
سال: 1987
ISSN: 0007-5124,1881-7122
DOI: 10.1538/expanim1978.36.3_261